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The authors have not commented on the availability of underlying data to support the overall results presented in Fig 2B, which suggest that rectangular portions of the image was selectively enhanced or otherwise manipulated in these areas. The PLOS Biology Editors remain concerned about the integrity issues surrounding the preparation of Fig 2B, although the PLOS Biology. Although overall the data provided by the authors support the overall results presented in Fig 2B, the PLOS Biology Editors remain concerned about the integrity issues surrounding the preparation of Fig 2B,. Specifically, Concerns were aldactone side effects raised for several figures in this article, including panels of Figs 2C, 4F, 4G and 5B. Specifically, Concerns were raised about discontinuities in the raw image as in the.

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